金台診所醫學美容的部落格

Anti-glaucoma drugs in pregnant and lactating women is always debatable issue…

On request from my dear colleague 

summarized in the following points about anti-glaucoma drugs in pregnant and lactating woman

 if newly discovered with low risk or glaucoma suspect we can postpone ttt until the 2nd trimester( specially if we know that IOP usually decrease during pregnancy naturally)

 if high risk we can start with beta blockers, alpha agonist, topical CAIs ( the lowest dose and frequency) but stop beta blockers and alpha agonist at 8th month to avoid side effects on the fetus during labor

 ALT and SLT is also an option

 PG absolutely contraindicated during pregnancy as it may precipitate premature uterine contractions and abortion.

 systemic CAI contraindicated in pregnancy and lactating woman ( teratogenic and metabolic acidosis with renal failure)

Anti-glaucoma drugs in pregnant and lactating women power point presentations:

Anti-glaucoma Drugs (Ocular Pharmacology)

Anti-glaucoma Drugs (Ocular Pharmacology)
Presentation Layout
 Introduction to glaucoma
 Anti glaucoma drugs:
– Classification
– Indications
– Contraindications
 Summary

Mode of action of anti glaucoma drugs
Beta blocker-decrease aqueous secretion
Miotics -increase trabecular outflow
Adrenergic agonist-decrease aqueous secretion
Prostaglandin-increase trabecular and uveaoscleral outflow
Carbonic anhydrase inhibitor-decrease aqueous secretion

For Further Reading
 Clinical Ocular Pharmacology by Jimmy D Balett
 Ophthalmic Drugs by Graham Hopkins & Richard Pearson
 Comprehensive Ophthalmology by A.K. Khurana
 AAO-Section 10-Glaucoma
 AAO-Section 2-Fundamentals & Principles of Ophthalmology
 Internet

Medical Treatment of Glaucoma Fritz Allen ,MD Visionary Ophthalmology

Pharmacotherapy of . Glaucoma Dr Manjuprasad Moderator: Dr Vijayalaxmi M.K

Glaucoma – ancient greek meaning clouded or blue- green hue • In Hippocratic aphorisms Glaucoma – blindness coming from advancing years • Second leading cause of blindness. Glaucoma is not a single disease process but a group of disorders characterized by a progressive optic neuropathy resulting in a characteristic appearance of optic disc & specific pattern of irreversible visual field defects that are associated frequently but not invariably with ↑IOP. Classification • Congenital glaucoma – Primary congenital glaucoma – Developmental glaucoma • Primary adult glaucoma – Primary open angle glaucoma – Primary angle closure glaucoma – Primary mixed mechanism glaucoma • Secondary glaucoma. Pathogenesis • All types of glaucoma – progressive optic neuropathy due to the death of retinal ganglion cells(RGCs) • RGCs death is initiated – block in transport of neurotrophins from brain to RGCs damaging cascade activation Apoptosis of RGCs • RGCs death – loss of retinal fibers – optic neuropathy & visual field defects.