Guillain-Barré Syndrome (GBS)

 set of related disorders characterized by an acute-onset, immune-mediated polyneuropathy.

 commonly associated with a preceding viral infection.

 The GBS subtypes are differentiated primarily by their clinical features and neurophysiologic findings.

 The relevance of these subtypes is better applied to prognosis than to treatment, which is nearly identical for all subtypes.

 GBS is considered a neurological emergency because it can exhibit sudden respiratory failure or cardiac arrhythmias, both of which can be fatal if they are unanticipated and untreated.

 The mortality rate for GBS is around 3% however, most patients make an excellent recovery.

All forms ofGuillain-Barré Syndromemanifest with clinical features:

 Flaccid weakness
 Hyporeflexia
 dysautonomia

The five subtypes ofGuillain-Barré Syndrome

 Acute inflammatory demyelinating polyneuropathy (AIDP)

 Acute motor-axonal neuropathy (AMAN)

 Acute motor-sensory axonal neuropathy (AMSAN)

 Miller-Fisher syndrome (MFS)

 Chronic inflammatory demyelinating polyneuropathy (CIDP)

Miller Fisher syndrome inGuillain-Barré Syndrome
 rare
 acquired variant of Guillain-Barré syndrome.
 abnormal muscle coordination
 paralysis of the eye muscles ( ophthalmoplegia)
 acute dilated tonic pupil with ( light and near responses)
 ptosis
 absence of the tendon reflexes
 preceded by a viral illness.
 generalized muscle weakness
 respiratory failure.
 dysautonomia
 unique antibody (Serum anti-GQ1b IgG ) is associated with ophthalmoplegia in Miller Fisher syndrome and Guillain-Barré syndrome

Treatment inGuillain-Barré Syndrome
for Miller Fisher syndrome is identical to treatment for Guillain-Barré syndrome

 intravenous immunoglobulin (IVIg)

 plasmapheresis

 symptomatic and supportive care.

The prognosis inGuillain-Barré Syndrome
 Miller Fisher syndrome has good prognosis .

 recovery begins within 2 to 4 weeks of the onset of symptoms, and may be almost complete within 6 months.

 Some individuals are left with residual deficits.

 Relapses may occur rarely (in less than 3 percent of cases).

The home message inGuillain-Barré Syndrome

In Acute Bilateral tonic pupil or ophthalmoplegia especially if preceded by viral or bacterial iIlnness should direct u to think of GBS ( Miller fisher syndrome) specially in kids and young adults

Guillain-Barré Syndrome (GBS) power point presentations:

Guillain-Barré Syndrome

Guillain-Barré syndrome Suhail Allaqaband Sinai Samaritan Medical Center Milwaukee, WI

Gullian barre syndrome

Definition GB syndrome is an acute polyneuropathic disorder affecting the peripheral nervous system medical encyclopedia GB syndrome is the problem that cause muscle weakness ,loss of reflexes and numbness of your arms and face or other parts of the body. GB syndrome is a disorder in which the body immune system attacks the parts of the peripheral nervous system .the first symptoms of the disorder include varying degree of weakness or tingling sensation in the legs factsheets:neurology. Etiology 1.Autoimmune reaction 2.Bactetial infection 3.Gastro and respiratory tract infection 4.Vaccines 5.Medication.Classification 1.Acute inflammatory demyelinating polyneropathy 2.Miller fisher sydrome 3.Acute motor axonal neuropathy 4.Acute motor sensory axonal neuropathy 5.Acute panautonomic neuropathy 6.Bickerstaff’s brain stem encephalitis

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Guillain-Barré Syndrome (GBS) 101

Guillain-Barre Syndrome

Guillain-Barré Syndrome (GBS)